Academic Studies and Publications
Studies and Publications Utilising Disease-Specific Treatment Data
The Real-World Data collected from BCB Medical’s Clinical Information Management Systems are widely used in medical research and in the publication of scientific articles.
Below is a list of publications that have applied data collection methods that meet scientific research criteria and are ethically sustainable, utilising patient-specific data contained and produced by BCB Medical’s Clinical Information Management System.
Cardiology
Littmann K., Kindborg G., Lidin M., Mellbin L., Eriksson Hogling D., & Brinck J. (2025). Development and implementation of a digiphysical screening model with nationwide reach to diagnose familial hypercholesterolemia. Digital Health, 11 (1-7)
Lumikari, T.J., Putaala, J., Kerola, A., Sibolt, G., Pirinen, J., Pakarinen, S., Lehto, M., & Nieminen, T., (2019). Continuous 4-week ECG monitoring with adhesive electrodes reveals AF in patients with recent embolic stroke of undetermined source. Annals of Noninvasive Electrocardiology, 24 (5).
Gastroenterology and GI surgery
Eriksson C, Visuri I, Vigren L, et al.: Clinical effectiveness of golimumab in ulcerative colitis: a prospective multicentre study based on the Swedish IBD Quality Register, SWIBREG. Scand J Gastroenterol. 2021, 56:1304-11. 10.1080/00365521.2021.1963466
Haijanen, J., Sippola, S. Grönroos, J., Rautio, T., Nordström, P., Rantanen, T., Aarnio M., Ilves, I., Hurme, S., Marttila, H., Virtanen, J., Mattila, A., Paajanen H. & Salminen, P. (2018). Optimising the antibiotic treatment of uncomplicated acute appendicitis: a protocol for a multicentre randomised clinical trial (APPAC II trial). On behalf of the APPAC study group. BMC Surgery, 18 (1).
Puolanne, A-M., Quadri, S., Vesterinen T., Hiltunen, S., Mustonen A., Kurki, S., Kolho, K-L., Arola, J., & Färkkilä, M. (2022) Can dysplasia surveillance be better targeted in ulcerative colitis by using faecal calprotectin? Scandinavian Journal of Gastroenterology, Epub June 13, 2022.
Rapo, M., Molander, P., af Björkesten, CG. et al. (2025) Correlation of a clinical activity index in comparison to frequently measured laboratory values in inflammatory bowel disease. Int J Colorectal Dis 40, 45 .
Saarinen, T., Kettunen, U., Pietiläinen, K.H., & Juuti, A. (2018). Is preoperative gastroscopy necessary before sleeve gastrectomy and Roux-en-Y gastric bypass? Surgery for obesity and related diseases, 14.
Sippola, S., Grönroos, J., Sallinen, V., Rautio, T., Nordström, P., Rantanen, T., Hurme, S., Leppäniemi, A., Meriläinen, S., Virtanen, J., & Salminen, P. (2018). A randomised placebocontrolled double-blind multicentre trial comparing antibiotic therapy with placebo in the treatment of uncomplicated acute appendicitis: APPAC III trial study protocol. BMJ Open, 8 (11).
Stenberg E, Everhov ÅH, Söderling J, Ottosson J, Osooli M; SWIBREG study group; Andersson E, Bergemalm D, Ludvigsson JF, Eriksson C, Olén O. Outcomes of inflammatory bowel disease in patients with obesity following bariatric surgery: propensity score-matched cohort study. BJS Open. 2025 Jul 1;9(4):zraf086. doi: 10.1093/bjsopen/zraf086. PMID: 40802498; PMCID: PMC12345414
Älgå, L.L., Ekheden, I., Thuresson, M. et al. Risk of primary sclerosing cholangitis among patients with gastritis: a nationwide cohort study. Eur J Epidemiol (2025).
Infectious diseases
Aho, I., Kivelä, P., Kaijomaa, M., Surcel, H-M., Ristola, M., Heikinheimo, O., Sutinen,, J. with the FINHIVPREG Study Team (2018). Comprehensive nationwide analysis of mother-to-child HIV transmission in Finland from 1983 to 2013. Epidemiology and Infection, 146 (10).
Aho, I., Kaijomaa, Kivelä, P., M.,Surcel, H-M., Sutinen, J., Heikinheimo, O. with the FINHIVPREG Study team. (2018). Most women living with HIV can deliver vaginally – National data from Finland 1993-2013. PLoS One, 13 (3).
Aho, I., Kivelä, P., Haukka, J., Sutinen, J., & Heikinheimo, O. (2017). Declining prevalence of cytological squamous intraepithelial lesions of the cervix among women living with wellcontrolled HIV – Most women living with HIV do not need annual PAP smear screening. Acta Obstet Gynecol Scand, 96 (11).
Carlander, C., Brännström, J., Månsson, F., Elvstam, O., Albinsson, P., Blom, S., Mattson, L., Hovmöller, S., Norrgren, H., Mellgren, Å., Svedhem, V., Gisslen, M., &Sönnerborg, A. (2023). Cohort profile: InfCareHIV, a prospective registry-based cohort study of people with diagnosed HIV in Sweden. BMJ Open.
Gokengin, D., Aho, I., Sarıgül Yıldırım, F., Bukovinova, P., Siwak, E., Papadopoulos, A., Sedlacek, D.,& Kowalska, J. (2019). Exposure to dolutegravir in pregnant women living with HIV in Central and Eastern Europe and neighbouring countries – data from the ECEE Network Group. Ginekol Pol, 90 (7).
Holmberg, V., Soini, H., Kivelä, P., Ollgren, J., & Ristola, M. (2019). Epidemiology and outcome of HIV patients in Finland co-infected with tuberculosis 1998-2015. BMC Infectious Diseases, 19, 264. [Cited 2022-08-25].
Kauppinen, KJ., Kivelä, P., & Sutinen, J. (2019). Switching from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide Significantly Worsens the Lipid Profile in a Real-World Setting. AIDS Patient Care and STDS, 33 (12). [Cited 2022-08-25].
Kluger, N., Blomqvist, C., & Kivelä, P. (2019). Kaposi sarcoma in Southern Finland (2006-2018). Int J Dermatol, 58 (11).
Moseholm, E., Fetters, M., Aho, I., Mellgren, A., Johansen, I., Storgaard, M., Pedersen, G., Katzenstein, T., & Weis, N. (2019). Study Protocol: becoming and being a mother living with HIV – a multicentre longitudinal mixed methods study among pregnant women living with HIV, non-pregnant women living with HIV and pregnant women not living with HIV in a high income setting (the 2B MOM study). BMJ Open, 9 (10).
Mäntymäki, H., Mäkelä, K. T., Vahlberg, T., Hirviniemi, J., & Niinimäki, T. (2016). Modular to Monoblock: Difficulties of Detaching the M2a-MagnumTM Head Are Common in Metal-on-metal Revisions. Clinical Orthopaedics and Related Research, 474 (9). [Cited 2022-08-25].
Neurology
Ala-Seppälä, H., Heino, I., Frantzén, J., Takala, R.S.K., Katila, A.J., Kyllönen, A., Maanpää, H-R., Posti, JP., Tallus, J., & Tenovuo, O. (2016). Injury profiles, demography and representativeness of patients with TBI attending a regional emergency department. Brain Injury, 30 (9).
Girfanova M, Martinez-Majander N, Mannismäki L, Sibolt G, Tiainen M, Curtze S. Retrospective analysis of 80 patients diagnosed with reversible cerebral vasoconstriction syndrome in the Helsinki Metropolitan Area. Eur J Neurol. 2025 Feb;32(2):e16564. doi: 10.1111/ene.16564.
Ilinca, A., Martinez-Majander, N., Samuelsson, S., Piccinelli, P., Truve, K., Cole, J., Kittner, S., Soller, M., Kristoffersson, U., Tatlisumak, T., Puschmann, A., Putaala, J., & Lindgren, A. (2020). Wholeexome sequencing in 22 young ischemic stroke patients with familial clustering of stroke. Stroke, 51 (4).
Isokuortti H, Virta JJ, Curtze S, Tiainen M. One-Year Survival of Ischemic Stroke Patients Requiring Mechanical Ventilation. Neurocrit Care. 2023 Feb 9. doi: 10.1007/s12028-023-01674-9. Online ahead of print.
Mannismäki L, Martinez-Majander N, Suomalainen O, Sibolt G, Girfanova M, Nybondas M, Nissinen H, Curtze S. Comparison of functional and safety outcomes between the extended versus early time window after intravenous thrombolysis and endovascular thrombectomy. J Neurol Sci. 2024 Jul 15:462:123107. doi: 10.1016/j.jns.2024.123107. Epub 2024 Jun 22.
Mannismäki L, Martinez-Majander N, Sibolt G, Suomalainen OP, Bäcklund K, Abou Elseoud A, Järveläinen J, Forss N, Curtze S. Association of admission plasma glucose level and cerebral computed tomographic perfusion deficit volumes. J Neurol Sci. 2023 Aug 15;451:120722. doi: 10.1016/j.jns.2023.120722. Epub 2023 Jun 26.
Mironova M, Kortela E, Kurkela S, Kanerva M, Curtze S. Lyme neuroborreliosis-associated cerebrovascular events in the Finnish endemic area. J Neurol Sci. 2021 Aug 15;427:117544. doi: 10.1016/j.jns.2021.117544. Epub 2021 Jun 17.
Polymeris, AA., Curtze, S., Erdur, H., Hametner, C., Heldner, MR., Groot, AE., Zini, A., Béjot, Y., Dietrich, A., Martinez-Majander, N., von Rennenberg, R., Gumbinger, C., Schaedelin, S., De Marchis, GM., Thilemann, S., Traenka, C., Lyrer, PA., Bonati, LH., Wegener, S., Ringleb, PA., Tatlisumak, T., Nolte, CH., Scheitz, JF., Arnold, M., Strbian, D., Nederkoorn, PJ., Gensicke, H., & Engelter, ST; TRISP Collaborators. (2019). Intravenous thrombolysis for suspected ischemic stroke with seizure at onset. Ann Neurol, 86 (5).
Richardt A, Aarnio K, Korhonen A, Rantanen K, Verho L, Curtze S, Laivuori H, Gissler M, Tikkanen M, Ijäs P. Acute recanalization therapy for ischemic stroke during pregnancy and puerperium. J Neurol. 2024 Apr 3. doi: 10.1007/s00415-024-12313-4. Online ahead of print.
Räty S, Martinez-Majander N, Suomalainen O, Sibolt G, Tiainen M, Valkonen K, Sairanen T, Forss N, Curtze S. Is the weekend effect true in acute stroke patients at tertiary stroke center? J Neurol Sci. 2021 Aug 15;427:117557.
Spaander, FH., Zinkstok, SM., Baharoglu, IM., Gensicke, H., Polymeris, A., Traenka, C., Hametner, C., Ringleb, P., Curtze, S., Martinez-Majander, N., Aarnio, K., Nolte, CH., Scheitz, JF., Leys, D., Hochart, A., Padjen, V., Kägi, G., Pezzini, A., Michel, P., Bill, O., Zini, A., Engelter, ST., Nederkoorn, PJ; Thrombolysis in Ischemic Stroke Patients Collaborators (TrISP). (2017). Sex Differences and Functional Outcome After Intravenous Thrombolysis. Stroke, 48 (3).
Suomalainen OP, Martinez-Majander N, Sibolt G, Bäcklund K, Järveläinen J, Korvenoja A, Tiainen M, Forss N, Curtze S. Comparative analysis of core and perfusion lesion volumes between commercially available computed tomography perfusion software. European Stroke Journal. 2023 Mar;8(1):259-267. doi: 10.1177/23969873221135915
Suomalainen OP, Elseoud Abou A, Martinez-Majander N, Tiainen M, Valkonen K, Virtanen P, Forss N, Curtze S. Is infarct core growth linear? Infarct volume estimation by computed tomography perfusion imaging. Acta Neurol Scand. 2022 Jun;145(6):684-691. doi: 10.1111/ane.13601. Epub 2022 Feb 21.
Suomalainen OP, Elseoud AA, Martinez-Majander N, Tiainen M, Forss N, Curtze S. Comparison of automated infarct core volume measures between non-contrast computed tomography and perfusion imaging in acute stroke code patients evaluated for potential endovascular treatment. J Neurol Sci. 2021 Jul 15;426:117483. doi: 10.1016/j.jns.2021.117483. Epub 2021 May 8.
Valkonen K, Martinez-Majander N, Sibolt G, Tiainen M, Räty S, Kokkonen T, Lappalainen K, Curtze S. Recanalization treatment for acute ischemic stroke: 3-month outcome before and after implementation of routine endovascular treatment. eNeurologicalSci. 2022 Feb 26;27:100394. doi: 10.1016/j.ensci.2022.100394. eCollection 2022 Jun.
Välimäki, M., Mishina, K., Kaakinen, JK., Holm, SK., Vahlo, J., Kirjonen, M., Pekurinen, V., Tenovuo, O., Korkeila, J, Hämäläinen, H., Sarajuuri, J., Rantanen, P., Orenius, T., & Koponen, A. (2018). Digital Gaming for Improving the Functioning of People With Traumatic Brain Injury: Randomized Clinical Feasibility Study. J Med Internet Res, 20 (3).
Zonneveld, TP., Curtze, S., Zinkstok, SM., Gensicke, H., Moulin, S., Scheitz, JF., Seiffge, DJ., Hametner, C., Heldner, MR., Traenka, C., Erdur, H., Baharoglu, I., Martinez-Majander, N., Pezzini, A., Zini, A., Padjen, V., Correia, PN., Strbian, D., Michel, P., Béjot, Y., Arnold, M., Leys, D., Ringleb, PA., Tatlisumak, T., Nolte, CH., Engelter, ST., Nederkoorn, PJ; TRISP collaborators. (2018). Non-office-hours admission affects intravenous thrombolysis treatment times and clinical outcome. J Neurol Neurosurg Psychiatry, 89 (9).
Valkonen K, Martinez-Majander N, Sibolt G, Tiainen M, Räty S, Kokkonen T, Lappalainen K, Curtze S. Recanalization treatment for acute ischemic stroke: 3-month outcome before and after implementation of routine endovascular treatment. eNeurologicalSci. 2022 Feb 26;27:100394. doi: 10.1016/j.ensci.2022.100394. eCollection 2022 Jun.
Ophtalmology
Hecht, I., Dubinsky-Pertzov, B., Karesvuo, P., Achiron, A. & Tuuminen, R. (2020). Association between intraocular lens diopter and posterior capsular opacification. Clinical and Experimental Ophthalmology, 48 (7).
Hecht, I., Karesvuo, P., Achironce, A., Elbazcf, U., Laine, I. & Tuuminen, R. (2020). Antiinflammatory Medication After Cataract Surgery and Posterior Capsular Opacification. American Journal of Ophthalmology, 215.
Loukovaara, S., Lehtinen, V., Nieminen, R., & Moilanen, J. (2019). Topical levofloxacin, nepafenac and prednisolone acetate medication after cataract surgery in the biggest tertiary eye hospital in Finland during 2015-2018. Acta Ophthalmologica, 97 (6).
Mokka, J., Keemu, H., Koivisto, M., Stormi, T., Vahlberg, T., Virolainen, P., Junnila, M., Seppänen, M., & Mäkelä, K.T. (2013). Experience of structural onlay allografts for the treatment of bone deficiency in revision total hip arthroplasty. Scand J Surg, 102 (4). [Cited 2022-08-25].
Orthopaedics
Koivisto, S.-T., Helenius, I., Stenroos, A., Ahola, J.-A., & Laaksonen, T. (2025). Proximal femoral fractures in children: incidence, complications, and functional outcomes—a population-based study from Finland. Acta Orthopaedica, 96, 726–734.
Koivisto ST, Laaksonen T, Helenius I, Vasara H, Stenroos A. Epidemiology and risk factors for premature physeal closure in distal femur fractures. Acta Orthop. 2023 Jul 12;94:348-353.
Koivisto, S-T., Laaksonen, T., Ahola, J-A., Heleniu, I. & Stenroos, A. (2022). Epidemiology and management of proximal tibia fractures in children and adolescents: a population-based study based on the Kids’ Fracture Tool. Acta Orthopaedica, 93 (826-830).
Laaksonen T, Kosola J, Nietosvaara N, Puhakka J, Nietosvaara Y, Stenroos A. Epidemiology, Treatment, and Treatment Quality of Overriding Distal Metaphyseal Radial Fractures in Children and Adolescents. J Bone Joint Surg Am. 2022 Feb 2;104(3):207-214.
Laaksonen T, Puhakka J, Stenroos A, Kosola J, Ahonen M, Nietosvaara Y. Cast immobilization in bayonet position versus reduction and pin fixation of overriding distal metaphyseal radius fractures in children under ten years of age: a case control
study. J Child Orthop. 2021 Feb 1;15(1):63-69.
Mokka, J., Keemu, H., Koivisto, M., Stormi, T., Vahlberg, T., Virolainen, P., Junnila, M., Seppänen, M., & Mäkelä, K.T. (2013). Experience of structural onlay allografts for the treatment of bone deficiency in revision total hip arthroplasty. Scand J Surg, 102 (4).
Mäntymäki, H., Mäkelä, K. T., Vahlberg, T., Hirviniemi, J., & Niinimäki, T. (2016). Modular to Monoblock: Difficulties of Detaching the M2a-MagnumTM Head Are Common in Metal-on-metal Revisions. Clinical Orthopaedics and Related Research, 474 (9).
Pakarinen O, Ahonen M, Grahn P, Helenius I, Laaksonen T. Refractures in Children. J Bone Joint Surg Am. 2025 Mar 27. doi: 10.2106/JBJS.24.01014.
Stenroos, A., Kosola, J., Puhakka, J., Laaksonen, T., Ahonen, M. & Nietosvaara, Y. (2019). Routine radiographic follow-up is not necessary after physeal fractures of the distal tibia in children. Acta Orthopedica, 90 (6).
Zilliacus K, Nietosvaara Y, Helenius I, Kämppä N, Vuorimies I, Grahn P. Bado type III Monteggia fractures have a high injury- and treatment-related complication rate: a single center study of 73 fractures. Acta Orthop. 2024 Oct 14;95:600-606.
Zilliacus, K., Nietosvaara, Y., Helenius, I., Laaksonen, T., Ahonen, M., Grahn, P. (2023). The Risk of Nerve Injury in Pediatric Forearm Fractures. J Bone Joint Surg Am.
Johan Marjamaa, Jukka Huttunen, Jyrki Kankare, Antti Malmivaara, Katri Pernaa, Jyrki Salmenkivi, Liisa Pekkanen. The Finnish spine register (FinSpine): development, design, validation and utility. European Spine Journal, published online: 17 September 2023.
Äärimaa V, Kohtala K, Rantalaiho I, Ekman E, Mäkelä K, Taskinen HS, Ryösä A, Kostensalo J, Meronen S, Laaksonen I. A Comprehensive Approach to PROMs in Elective Orthopedic Surgery: Comparing Effect Sizes across Patient Subgroups. J Clin Med. 2024 May 24;13(11):3073. doi: 10.3390/jcm13113073. PMID: 38892784; PMCID
Äärimaa V, Kohtala K, Mäkelä K, Karvonen M, Arimaa A, Ryösä A, Kostensalo J, Kaivonen F, Laaksonen I. Comparative analysis of patient-reported outcomes in joint arthroplasty surgeries. PLoS One. 2024 Dec 23;19(12):e0314818. doi: 10.1371/journal.pone.0314818. PMID: 39715181; PMCID: PMC11666041
Others
Eriksson, I.M., Gordin, D., Shams, S., Forsblom, Summanen, P., C., Liebkind, R., Tatlisumak, T., Putaala, J., Groop, P-H., Martola, J., & Thorn, L.M., on behalf of the FinnDiane Study Group (2020). Nocturnal Blood Pressure Is Associated With Cerebral Small-Vessel Disease in Type 1 Diabetes. Behalf of the FinnDiane Study Group. Diabetes care, 43 (8).
Katz, Gregory, editor (2020) Implementing value-based health care in Europe: Handbook for pioneers. EIT Health.
Nieminen T, Tolvi M, Ylä-Kotola T, Lehtonen L, Mäkitie A, Ilmarinen T. Risk factors for early mortality and impaired quality of life in oral cavity cancer – head and neck cancer register study. Acta Oncol. 2025 Jul 3;64:859-867.
Rajala, S., Järvelä L.S., Huurre, A., Grönroos, M., Rautava, P., & Lähteenmäki, P.M. (2020). Use of electronic patient data storage for evaluating and setting the risk category of late effects in childhood cancer survivors. Pediatric Blood & Cancer, 67 (11).
Ruohoalho, J. (2018). Complications and Their Registration in Otorhinolaryngology – Head and Neck Surgery : Special Emphasis in Tonsil Surgery Quality Registration. University of Helsinki, Faculty of Medicine, Department of Otorhinolaryngology – Head and Neck Surgery. Helsingin yliopisto.
Saarni, S. E., Rosenström, T., Stenberg, J. H., Plattonen, A., Holi, M., Ekelund, J., … Saarni, S. I. (2022). Finnish Psychotherapy Quality Register: rationale, development, and baseline results. Nordic Journal of Psychiatry, 77(5), 455–466.
